Genetic link to poor tolerance to shift work identified

Genetic link to poor tolerance to shift work identified

658
SHARE

Today:- London, Nov – Some people are better able to handle constant disruptions to their daily rhythm caused by shift work than others due to certain genetic factors, a study has found.

Shift work often disrupts the circadian rhythm, which can lead to sleep disorders and daytime fatigue.

The study led by researchers at University of Helsinki in Finland showed that a common variation in the melatonin receptor 1A (MTNR1A) gene is linked to the job-related exhaustion experienced by shift workers.

Further, it established that the risk variation of the MTNR1A gene is probably related to the methylation of DNA in the regulatory sequence of the MTNR1A gene as well as the weaker expression of the MTNR1A gene.

The methylation of DNA is one of the epigenetic mechanisms regulating the functioning of the genome, influenced not only by variations in DNA sequence, but also environmental factors such as fluctuations in the circadian rhythm, the study said.

As it results in a smaller number of melatonin receptors, the risk variant of the gene can cause weaker natural melatonin signalling, one of the regulatory mechanisms in stabilising the circadian rhythm.

Moreover, the influence of the risk variant of the MTNR1A gene may explain the degree to which light exposure at night disrupts the circadian rhythm of shift workers, the researchers observed.

“The variant we have now discovered can only explain a small part of the variation between individuals, and it cannot be used as a basis to determine a person’s tolerance to shift work,” said Tiina Paunio, Professor at University of Helsinki in Finland.

The study was published in the journal Sleep.

IANS

155 COMMENTS

  1. Can I just say what a relief to seek out someone who truly is aware of what theyre speaking about on the internet. You definitely know easy methods to convey a problem to mild and make it important. Extra folks have to learn this and understand this facet of the story. I cant imagine youre no more well-liked because you undoubtedly have the gift.
    visite website http://freemusicallyfollowers.site/

  2. There are certainly quite a lot of details like that to take into consideration. That could be a nice point to convey up. I provide the ideas above as general inspiration but clearly there are questions just like the one you bring up where an important thing shall be working in sincere good faith. I don?t know if best practices have emerged round things like that, however I’m certain that your job is clearly identified as a good game. Each boys and girls really feel the influence of just a moment’s pleasure, for the remainder of their lives.
    shoes https://www.fanmerchstore.com/anime-black-butler-backpack-bleach-naruto-one-piece-fairy-tail-attack-on-titan-school-bags-women-men-travel/

  3. Nice post. I be taught one thing tougher on different blogs everyday. It should all the time be stimulating to read content material from other writers and follow just a little something from their store. I’d choose to use some with the content on my weblog whether you don’t mind. Natually I’ll provide you with a link in your internet blog. Thanks for sharing.
    Black Friday Hostgator https://hostgatorblackfriday.xyz

  4. Youre so cool! I dont suppose Ive learn something like this before. So good to search out somebody with some original ideas on this subject. realy thanks for beginning this up. this web site is one thing that’s needed on the internet, somebody with slightly originality. helpful job for bringing one thing new to the web!
    shadow fight 2 cheat http://shadowfight2hackmod.com

  5. Youre so cool! I dont suppose Ive learn something like this before. So nice to find any individual with some authentic ideas on this subject. realy thanks for beginning this up. this web site is one thing that is wanted on the internet, somebody with a little originality. helpful job for bringing one thing new to the web!
    Free web submission http://www.add-e.com/submitter

  6. A formidable share, I simply given this onto a colleague who was doing a bit analysis on this. And he in truth purchased me breakfast as a result of I discovered it for him.. smile. So let me reword that: Thnx for the deal with! However yeah Thnkx for spending the time to debate this, I really feel strongly about it and love studying extra on this topic. If doable, as you grow to be expertise, would you thoughts updating your blog with extra particulars? It is extremely helpful for me. Large thumb up for this weblog publish!
    telhadista http://manutencaoresidencial.srv.br/desentupidora/parque-joao-ramalho/

  7. Good post. I study something more challenging on different blogs everyday. It’ll all the time be stimulating to learn content from other writers and observe a bit of one thing from their store. I’d choose to make use of some with the content on my weblog whether or not you don’t mind. Natually I’ll offer you a hyperlink on your web blog. Thanks for sharing.
    Desentupidora https://hidrotex.com.br/dedetizadora/vila-patrimonial/

  8. The subsequent time I learn a weblog, I hope that it doesnt disappoint me as a lot as this one. I mean, I know it was my choice to learn, however I really thought youd have one thing attention-grabbing to say. All I hear is a bunch of whining about something that you could repair for those who werent too busy in search of attention.
    commercial kitchen equipment manufacturers in chennai http://www.variar.in/commercial-kitchen-equipments.html

  9. Youre so cool! I dont suppose Ive read anything like this before. So good to search out someone with some authentic ideas on this subject. realy thanks for beginning this up. this website is one thing that is needed on the internet, somebody with a little originality. useful job for bringing something new to the internet!
    m4ntiz https://www.instagram.com/m4ntis/

  10. A formidable share, I simply given this onto a colleague who was doing a little bit evaluation on this. And he in fact purchased me breakfast as a result of I found it for him.. smile. So let me reword that: Thnx for the treat! However yeah Thnkx for spending the time to debate this, I feel strongly about it and love reading more on this topic. If attainable, as you develop into expertise, would you thoughts updating your weblog with extra particulars? It’s extremely useful for me. Huge thumb up for this blog post!
    click here http://2ch-ranking.net/redirect.php?url=http://lumberjocks.com/hassanjantzen3

  11. There are actually a variety of details like that to take into consideration. That is a nice point to convey up. I offer the ideas above as basic inspiration but clearly there are questions like the one you convey up the place a very powerful thing can be working in honest good faith. I don?t know if best practices have emerged around things like that, but I am certain that your job is clearly identified as a fair game. Each girls and boys really feel the affect of only a moment’s pleasure, for the rest of their lives.
    Desentupidora http://dedetizadora.space/desentupidora/jardim-record/

  12. Youre so cool! I dont suppose Ive read anything like this before. So nice to seek out somebody with some unique ideas on this subject. realy thanks for beginning this up. this website is one thing that’s needed on the internet, someone with a little originality. helpful job for bringing something new to the web!

  13. The subsequent time I learn a weblog, I hope that it doesnt disappoint me as much as this one. I mean, I do know it was my choice to learn, however I actually thought youd have one thing interesting to say. All I hear is a bunch of whining about something that you could possibly fix should you werent too busy in search of attention.

  14. There are actually quite a lot of particulars like that to take into consideration. That could be a nice point to bring up. I offer the ideas above as general inspiration however clearly there are questions like the one you deliver up the place a very powerful factor can be working in honest good faith. I don?t know if greatest practices have emerged round things like that, however I’m certain that your job is clearly recognized as a fair game. Both girls and boys really feel the influence of just a moment’s pleasure, for the remainder of their lives.

  15. Nice post. I learn something more difficult on completely different blogs everyday. It will all the time be stimulating to read content material from other writers and observe a little bit one thing from their store. I’d prefer to use some with the content on my blog whether or not you don’t mind. Natually I’ll give you a hyperlink in your web blog. Thanks for sharing.

  16. Can I just say what a relief to find somebody who actually knows what theyre speaking about on the internet. You positively know how one can bring a problem to light and make it important. Extra folks need to read this and understand this side of the story. I cant consider youre no more in style since you positively have the gift.

  17. There are some attention-grabbing time limits in this article however I don’t know if I see all of them heart to heart. There is some validity but I will take hold opinion till I look into it further. Good article , thanks and we want more! Added to FeedBurner as nicely

  18. When I initially commented I clicked the -Notify me when new feedback are added- checkbox and now every time a comment is added I get 4 emails with the identical comment. Is there any means you can take away me from that service? Thanks!

  19. There are definitely numerous details like that to take into consideration. That is a great level to deliver up. I offer the thoughts above as general inspiration however clearly there are questions like the one you carry up where the most important thing shall be working in honest good faith. I don?t know if best practices have emerged round issues like that, but I am sure that your job is clearly identified as a fair game. Both boys and girls really feel the impression of just a moment’s pleasure, for the remainder of their lives.

  20. Youre so cool! I dont suppose Ive read something like this before. So nice to search out someone with some original ideas on this subject. realy thanks for starting this up. this web site is something that’s wanted on the web, someone with slightly originality. helpful job for bringing one thing new to the internet!

  21. I was very pleased to seek out this internet-site.I needed to thanks to your time for this excellent learn!! I definitely having fun with every little bit of it and I have you bookmarked to check out new stuff you blog post.

  22. An fascinating discussion is value comment. I feel that it’s best to write extra on this subject, it may not be a taboo topic but typically persons are not sufficient to talk on such topics. To the next. Cheers

  23. Youre so cool! I dont suppose Ive learn anything like this before. So nice to search out someone with some unique ideas on this subject. realy thanks for starting this up. this web site is something that’s wanted on the web, somebody with somewhat originality. useful job for bringing something new to the internet!

  24. A formidable share, I simply given this onto a colleague who was doing a little bit analysis on this. And he in fact bought me breakfast as a result of I discovered it for him.. smile. So let me reword that: Thnx for the treat! But yeah Thnkx for spending the time to debate this, I feel strongly about it and love studying extra on this topic. If potential, as you turn into expertise, would you thoughts updating your weblog with more particulars? It is extremely helpful for me. Big thumb up for this blog submit!

  25. That is the best weblog for anyone who needs to find out about this topic. You realize so much its almost exhausting to argue with you (not that I really would want…HaHa). You positively put a new spin on a topic thats been written about for years. Great stuff, simply nice!

  26. Hi there! I just wish to give an enormous thumbs up for the great data you’ve here on this post. I shall be coming again to your weblog for extra soon.

  27. An interesting dialogue is worth comment. I think that you should write extra on this matter, it might not be a taboo topic but typically persons are not sufficient to talk on such topics. To the next. Cheers

  28. I used to be very pleased to search out this web-site.I wanted to thanks to your time for this wonderful learn!! I definitely enjoying each little bit of it and I have you bookmarked to take a look at new stuff you blog post.

  29. I used to be very pleased to search out this internet-site.I wanted to thanks to your time for this excellent read!! I positively enjoying every little bit of it and I’ve you bookmarked to check out new stuff you blog post.

  30. Youre so cool! I dont suppose Ive learn something like this before. So good to seek out anyone with some unique thoughts on this subject. realy thanks for beginning this up. this website is one thing that’s needed on the web, somebody with somewhat originality. helpful job for bringing something new to the web!

  31. Aw, this was a very nice post. In idea I would like to put in writing like this additionally – taking time and precise effort to make a very good article… however what can I say… I procrastinate alot and certainly not seem to get something done.

  32. There are definitely a number of details like that to take into consideration. That could be a great point to deliver up. I offer the thoughts above as general inspiration but clearly there are questions like the one you bring up the place a very powerful thing might be working in honest good faith. I don?t know if finest practices have emerged round issues like that, however I am certain that your job is clearly identified as a fair game. Each boys and girls really feel the influence of only a second’s pleasure, for the rest of their lives.

  33. An attention-grabbing discussion is value comment. I feel that it’s best to write more on this topic, it might not be a taboo subject but generally persons are not enough to speak on such topics. To the next. Cheers

  34. I am usually to blogging and i really respect your content. The article has actually peaks my interest. I’m going to bookmark your site and keep checking for new information.

  35. There are certainly a lot of details like that to take into consideration. That may be a great level to carry up. I offer the ideas above as common inspiration however clearly there are questions just like the one you carry up where an important factor will probably be working in trustworthy good faith. I don?t know if greatest practices have emerged round issues like that, however I’m sure that your job is clearly recognized as a fair game. Each boys and girls really feel the impact of only a second’s pleasure, for the remainder of their lives.

  36. Youre so cool! I dont suppose Ive learn anything like this before. So good to find someone with some original thoughts on this subject. realy thank you for starting this up. this website is one thing that is needed on the internet, somebody with somewhat originality. useful job for bringing something new to the internet!

  37. The following time I learn a blog, I hope that it doesnt disappoint me as a lot as this one. I mean, I do know it was my choice to learn, but I actually thought youd have something fascinating to say. All I hear is a bunch of whining about something that you possibly can fix if you werent too busy in search of attention.

  38. I’m impressed, I must say. Actually hardly ever do I encounter a weblog that’s both educative and entertaining, and let me tell you, you could have hit the nail on the head. Your idea is outstanding; the problem is one thing that not sufficient individuals are talking intelligently about. I’m very glad that I stumbled throughout this in my seek for something relating to this.

  39. I’d must verify with you here. Which isn’t one thing I usually do! I take pleasure in studying a post that will make folks think. Also, thanks for allowing me to comment!

  40. After examine a few of the blog posts in your web site now, and I really like your approach of blogging. I bookmarked it to my bookmark website checklist and can be checking again soon. Pls try my web site as well and let me know what you think.

  41. The next time I learn a blog, I hope that it doesnt disappoint me as a lot as this one. I mean, I do know it was my option to learn, but I actually thought youd have one thing attention-grabbing to say. All I hear is a bunch of whining about something that you could fix if you happen to werent too busy on the lookout for attention.

  42. The following time I learn a weblog, I hope that it doesnt disappoint me as a lot as this one. I mean, I do know it was my option to read, but I truly thought youd have something interesting to say. All I hear is a bunch of whining about something that you would fix should you werent too busy searching for attention.

  43. Can I just say what a relief to find somebody who truly knows what theyre speaking about on the internet. You undoubtedly know easy methods to bring an issue to mild and make it important. Extra individuals need to read this and understand this side of the story. I cant consider youre no more in style since you definitely have the gift.

  44. I discovered your blog website on google and check a number of of your early posts. Proceed to maintain up the very good operate. I simply additional up your RSS feed to my MSN Information Reader. In search of ahead to reading more from you afterward!…

  45. A formidable share, I simply given this onto a colleague who was doing a little bit analysis on this. And he in reality bought me breakfast as a result of I found it for him.. smile. So let me reword that: Thnx for the deal with! However yeah Thnkx for spending the time to discuss this, I feel strongly about it and love studying more on this topic. If doable, as you develop into experience, would you mind updating your weblog with more details? It’s highly useful for me. Massive thumb up for this weblog publish!

  46. After study just a few of the weblog posts in your web site now, and I truly like your manner of blogging. I bookmarked it to my bookmark web site listing and will probably be checking back soon. Pls take a look at my site as well and let me know what you think.

  47. Can I simply say what a relief to search out someone who really is aware of what theyre talking about on the internet. You undoubtedly know how to convey a difficulty to gentle and make it important. Extra people must learn this and understand this aspect of the story. I cant consider youre not more widespread since you positively have the gift.

  48. The subsequent time I read a blog, I hope that it doesnt disappoint me as much as this one. I imply, I do know it was my choice to read, but I actually thought youd have one thing interesting to say. All I hear is a bunch of whining about one thing that you could repair when you werent too busy on the lookout for attention.

  49. I used to be more than happy to search out this web-site.I needed to thanks for your time for this wonderful read!! I definitely having fun with every little little bit of it and I’ve you bookmarked to check out new stuff you weblog post.

  50. There are some interesting points in time on this article but I don’t know if I see all of them heart to heart. There’s some validity but I’ll take maintain opinion until I look into it further. Good article , thanks and we want more! Added to FeedBurner as well

  51. I found your blog website on google and verify a couple of of your early posts. Continue to keep up the excellent operate. I simply additional up your RSS feed to my MSN News Reader. Searching for ahead to reading more from you later on!…

  52. Youre so cool! I dont suppose Ive learn anything like this before. So nice to seek out anyone with some original ideas on this subject. realy thanks for beginning this up. this website is something that is needed on the net, someone with a little originality. helpful job for bringing something new to the internet!

  53. Can I simply say what a relief to find somebody who really knows what theyre speaking about on the internet. You definitely know learn how to convey a problem to light and make it important. More individuals need to read this and perceive this side of the story. I cant believe youre no more popular since you definitely have the gift.

  54. Can I just say what a relief to search out somebody who actually knows what theyre speaking about on the internet. You positively know how you can bring a problem to light and make it important. More individuals must learn this and understand this facet of the story. I cant imagine youre not more common since you definitely have the gift.

  55. After I initially commented I clicked the -Notify me when new comments are added- checkbox and now each time a remark is added I get four emails with the identical comment. Is there any approach you’ll be able to take away me from that service? Thanks!

  56. Oh my goodness! a tremendous article dude. Thank you Nonetheless I am experiencing challenge with ur rss . Don’t know why Unable to subscribe to it. Is there anybody getting an identical rss drawback? Anyone who is aware of kindly respond. Thnkx

  57. There are actually plenty of particulars like that to take into consideration. That could be a nice point to convey up. I supply the ideas above as basic inspiration however clearly there are questions like the one you convey up the place an important thing will be working in trustworthy good faith. I don?t know if greatest practices have emerged around issues like that, however I am positive that your job is clearly recognized as a good game. Both girls and boys feel the impact of just a moment’s pleasure, for the remainder of their lives.

  58. Aw, this was a really nice post. In concept I want to put in writing like this moreover – taking time and actual effort to make a very good article… but what can I say… I procrastinate alot and not at all appear to get one thing done.

  59. Spot on with this write-up, I actually assume this website needs way more consideration. I’ll most likely be once more to read way more, thanks for that info.

  60. Nice post. I be taught one thing tougher on different blogs everyday. It is going to at all times be stimulating to read content from different writers and follow somewhat one thing from their store. I’d desire to make use of some with the content on my blog whether you don’t mind. Natually I’ll provide you with a hyperlink on your web blog. Thanks for sharing.

  61. Once I initially commented I clicked the -Notify me when new feedback are added- checkbox and now every time a remark is added I get 4 emails with the same comment. Is there any means you may take away me from that service? Thanks!

  62. This is the precise blog for anybody who needs to search out out about this topic. You notice so much its nearly hard to argue with you (not that I actually would need…HaHa). You positively put a new spin on a topic thats been written about for years. Nice stuff, simply nice!

  63. When I originally commented I clicked the -Notify me when new feedback are added- checkbox and now every time a remark is added I get four emails with the identical comment. Is there any method you possibly can remove me from that service? Thanks!

  64. I’m impressed, I must say. Really not often do I encounter a weblog that’s each educative and entertaining, and let me inform you, you’ve gotten hit the nail on the head. Your idea is excellent; the difficulty is one thing that not enough individuals are speaking intelligently about. I am very completely satisfied that I stumbled across this in my search for something relating to this.

  65. There are some interesting time limits on this article however I don’t know if I see all of them middle to heart. There is some validity but I will take hold opinion until I look into it further. Good article , thanks and we want extra! Added to FeedBurner as effectively

LEAVE A REPLY