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‘Super-smart mice’ may help cure Alzheimer’s, schizophrenia

Today:- Scientists have created intelligent and bold mice by altering a single gene, an advance that may pave the way for new treatments for brain disorders such as Alzheimer’s, schizophrenia and post-traumatic stress disorder (PTSD).

The unusually intelligent mice were created by altering a single gene and as a result the mice were also less likely to feel anxiety or recall fear.

The study, led by researchers at the University of Leeds in UK and Mount Sinai Hospital in Toronto, sheds light on the molecular underpinnings of learning and memory and could form the basis for research into new treatments for age-related
cognitive decline, cognitive disorders such as Alzheimer’s disease and schizophrenia, and other conditions.

Researchers altered a gene to inhibit the activity of an enzyme called phosphodiesterase-4B (PDE4B), which is present in many organs of the vertebrate body, including the brain. In behavioural tests, the PDE4B-inhibited mice showed enhanced cognitive abilities.

They tended to learn faster, remember events longer and solve complex exercises better than ordinary mice.

For example, the “brainy mice” showed a better ability than ordinary mice to recognise another mouse that they had been introduced to the day before.

They were also quicker at learning the location of a hidden escape platform in a test called the Morris water maze. The PDE4B-inhibited mice also showed less recall of a fearful event after several days than ordinary mice.
By: Teennews1 Network Team

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